That is such an interesting question! I honestly didn’t know but of course I did some research and apparently, Down Syndrome is actually a chromosome anomaly caused by the forming of a trisomy, or an extra chromosome in the Chromosome 21 pairing in the human body. Now, we humans have 23 chromosome pairings, but cats have 19 chromosome pairings. So, it’s physically impossible for cats to have a trisomy of the Chromosome 21 pairing, and therefore, have Down Syndrome!
But there are loads of physical and neurological abnormalities that cats can have including other chromosomal abnormalities. That’s why some of the cats have those special faces. But all cute any ways!